Main Street is a colloquial term used by economists to refer collectively to America's independent small businesses. It gets its name from a common name for the principal commercial street of small towns across the country. In England, the equivalent term is High Street.

In another context, the term Wall Street versus Main Street, with the former referring to big business and high finance. Nevertheless, those involved in big business and high finance spend a considerable amount of time trying to understand what products, fashions, brands, and trends succeed or fail on Main Street.